Determination of Embryotoxic effects of Atipamezole using in ovo model

Atipamezole is a specific α2-adrenergic receptor antagonist, and there exists insufficient information on its use during pregnancy. The aim of this study was to determine the embryotoxic activity through an in ovo method. During first stage study, 210 fertile eggs were divided into seven groups 30 placed incubator. On seventh day stage, no application made control group. second group administered 50 microliters (µL) saline solution, while other given at doses 250, 125, 62.5, 31.25 15.62 micrograms·egg-1 (µg·egg-1) µL solution. In according dose range determined from 150 five Fifty solution 220, 190 160 µg·egg-1 After incubation period, hatched, embryonic mortality rates calculated. rate be 39.3% highest (250 = 5 miligrams·kilograms-1 –mg·kg-1–) (P<0.05), same as (P>0.05). conclusion, it can stated that for very high compared recommended used pregnancy benefit-loss calculation when necessary. However molecular or histopathological studies regarding development organ drafts are necessary safety